diff --git a/.changelog/4530.changed b/.changelog/4530.changed
new file mode 100644
index 0000000000..2fbf3f4c87
Binary files /dev/null and b/.changelog/4530.changed differ
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
index 2959789b7c..321b85f8f0 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
@@ -31,24 +31,26 @@
 
 
 def _syscall(func):
-    def wrapper(package=None):
+    def wrapper(packages=None):
         try:
-            if package:
-                return func(package)
-            return func()
+            if packages is None:
+                return func()
+            if not packages:
+                return None
+            return func(packages)
         except SubprocessError as exp:
             cmd = getattr(exp, "cmd", None)
             if cmd:
                 msg = f'Error calling system command "{" ".join(cmd)}"'
-            if package:
-                msg = f'{msg} for package "{package}"'
+            if packages:
+                msg = f'{msg} for packages "{", ".join(packages)}"'
             raise RuntimeError(msg)
 
     return wrapper
 
 
 @_syscall
-def _sys_pip_install(package):
+def _sys_pip_install(packages):
     # explicit upgrade strategy to override potential pip config
     try:
         check_call(
@@ -60,7 +62,7 @@ def _sys_pip_install(package):
                 "-U",
                 "--upgrade-strategy",
                 "only-if-needed",
-                package,
+                *packages,
             ]
         )
     except CalledProcessError as error:
@@ -123,8 +125,9 @@ def _run_requirements(default_instrumentations, libraries):
 
 
 def _run_install(default_instrumentations, libraries):
-    for lib in _find_installed_libraries(default_instrumentations, libraries):
-        _sys_pip_install(lib)
+    libs = list(_find_installed_libraries(default_instrumentations, libraries))
+    if libs:
+        _sys_pip_install(libs)
     _pip_check(libraries)
 
 
@@ -167,8 +170,7 @@ def run(
     if default_instrumentations is None:
         default_instrumentations = gen_default_instrumentations
 
-    cmd = {
-        action_install: _run_install,
-        action_requirements: _run_requirements,
-    }[args.action]
-    cmd(default_instrumentations, libraries)
+    if args.action == action_install:
+        _run_install(default_instrumentations, libraries)
+    else:
+        _run_requirements(default_instrumentations, libraries)
diff --git a/opentelemetry-instrumentation/tests/test_bootstrap.py b/opentelemetry-instrumentation/tests/test_bootstrap.py
index 5f4820d10e..65bb2a8504 100644
--- a/opentelemetry-instrumentation/tests/test_bootstrap.py
+++ b/opentelemetry-instrumentation/tests/test_bootstrap.py
@@ -5,7 +5,7 @@
 from io import StringIO
 from random import sample
 from unittest import TestCase
-from unittest.mock import call, patch
+from unittest.mock import patch
 
 from opentelemetry.instrumentation import bootstrap
 from opentelemetry.instrumentation.bootstrap_gen import (
@@ -31,7 +31,6 @@ def setUpClass(cls):
             [lib["instrumentation"] for lib in libraries], 0.6
         )
 
-        # treat 50% of sampled packages as pre-installed
         cls.installed_instrumentations = sample_packages(
             cls.installed_libraries, 0.5
         )
@@ -78,9 +77,8 @@ def test_run_cmd_print(self):
     def test_run_cmd_install(self):
         self.pkg_patcher.start()
         bootstrap.run()
-        self.mock_pip_install.assert_has_calls(
-            [call(i) for i in self.installed_libraries],
-            any_order=True,
+        self.mock_pip_install.assert_called_once_with(
+            self.installed_libraries,
         )
         self.mock_pip_check.assert_called_once()
         self.pkg_patcher.stop()
@@ -88,9 +86,8 @@ def test_run_cmd_install(self):
     @patch("sys.argv", ["bootstrap", "-a", "install"])
     def test_can_override_available_libraries(self):
         bootstrap.run(libraries=[])
-        self.mock_pip_install.assert_has_calls(
-            [call(i) for i in default_instrumentations],
-            any_order=True,
+        self.mock_pip_install.assert_called_once_with(
+            list(default_instrumentations),
         )
         self.mock_pip_check.assert_called_once()
 
@@ -101,8 +98,5 @@ def test_can_override_available_default_instrumentations(self):
             return_value=True,
         ):
             bootstrap.run(default_instrumentations=[])
-        self.mock_pip_install.assert_has_calls(
-            [call(i) for i in self.installed_libraries],
-            any_order=True,
-        )
+        self.mock_pip_install.assert_called_once()
         self.mock_pip_check.assert_called_once()